JP1302 dihydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

JP1302 diHClide 是一种选择性、高亲和力的 α2C-肾上腺素受体 (α2C-adrenoceptor) 拮抗剂，Ki（结合亲和力）值为 28 nM，Kb 值（拮抗剂活性）为 16 nM。

JP1302 dihydrochloride is a selective, high affinity antagonist of the alpha2C-adrenoceptor (α2C-adrenoceptor), with a Ki (binding affinity) value of 28 nM and a Kb value (antagonist activity) of 16 nM.

——

Animal Model:Male Sprague Dawley rats (8 weeks old)Dosage:3 mg/kg Administration:IV, pre-treatment: administered 5 min before the induction of ischemia, post-treatment: injected 45 min after the initiation of reperfusion Result:Significantly ameliorated renal dysfunction in the rats at 24 h after reperfusion. post-ischemic administration of JP-1302 significantly ameliorated renal dysfunction, histological damage and reduced apoptotic cells and pro-inflammatory cytokine mRNA expression.

——

Angiogenesis

Adrenergic Receptor

NF-κB

——

——

1259314-65-2

441.4

C24H26Cl2N4

>98% (HPLC)

In Vitro:?H2O : 12.5 mg/mL (28.32 mM)

Cl.Cl.CN1CCN(CC1)c1ccc(Nc2c3ccccc3nc3ccccc23)cc1

——

(-20℃)

With Ice Pack

≥ 2 years